Elucidation of the Mechanism of IL-22-Mediated Suppression of β-Cell Stress in Diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1108077

Funding Status
Closed

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Funded Activity Summary

Pancreatic ?-cells produce the hormone insulin that controls blood sugar. Type 2 diabetes is characterized by inability of stressed ?-cells to make sufficient insulin to control blood sugar. We discovered that an immune factor, IL-22, protects ?-cells from stress. Treatment of diabetic mice with IL-22 resolves all the major problems in diabetes. This project seeks to reveal the mechanisms by which IL-22 protects ?-cells from stress, with potential for development of novel diabetes therapies.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $222,322.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytokine signalling | gene expression | islets of Langerhans | oxidative stress | type 2 diabetes mellitus (non-insulin dependent diabetes mellitus)

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