How does NF-kB2 regulate thymic selection to prevent organ-specific autoimmune disease?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1107464

Funding Status
Closed

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Funded Activity Summary

Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $787,600.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell receptor | autoimmune disease | thymus | tolerance | transcriptional regulation

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