The role of copper in Ubiquitin-dependent protein degradation in Alzheimer's disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1106091

Funding Status
Closed

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Funded Activity Summary

Ubiquitin’s are small proteins that tag other proteins in a process known as “Ubiquitination”. Often this is to target them for degradation once they are no longer needed i.e. to take out the rubbish. This process is disrupted in Alzheimer’s disease (AD), which may contribute to the disease. This project aims to find out if copper, an essential metal for life, is required for this process. Drugs that are designed to deliver copper to brain cells have been effective in small AD clinical trials.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Targeted Calls

Funding Amount: $588,622.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | amyloid precursor protein | copper deficiency | protein degradation | ubiquitination

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