Germinal centres, rogue B cells and the genesis of immunological diseases.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1105877

Funding Status
Closed

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Funded Activity Summary

This study will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in autoimmune diseases such as lupus. Targeted studies of a newly discovered "rogue" white blood cell will also provide new clues on how autoimmune diseases arise. In addition, modeling of human immunological disease in mice via CRISPR/Cas9 mutagenesis will provide valuable new insights into their causes and potential treatments.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Research Fellowships

Funding Amount: $753,300.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibody production | autoimmunity initiation | genetic engineering | germinal centre | selection

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