Positive and negative selection in the germinal centre reaction

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1105875

Funding Status
Closed

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Funded Activity Summary

We will investigate the processes that control the production of antibodies by the immune system. In particular, we will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in the case of autoimmune diseases such as lupus. Targeted studies of a new type of "rogue" white blood cell we have identified will also provide important clues on how autoantibody-producing cells escape and cause autoimmune disease.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $1,289,965.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibody production | autoimmunity initiation | genetic engineering | germinal centre | selection

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