Long-term macrolide therapy; oropharyngeal dysbiosis and the spread of resistant pathogens

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1104000

Funding Status
Closed

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Funded Activity Summary

Use of macrolide therapy for chronic lung diseases is increasing rapidly. We will determine the impact of long-term macrolide antibiotic use on upper airway bacteria in patients with lung disease, and assess its contribution to antibiotic resistance in the wider community. We will investigate the mechanism by which this therapy achieves benefit and assess interference with bacterial signalling as a means to improve treatment efficacy and reduce induction of antibiotic resistance.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $384,153.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibiotic resistance | bacterial infection | bronchiectasis | microbial ecology | respiratory infection

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