Mechanistic and Functional Drivers of Neochromosome Evolution

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1103685

Funding Status
Closed

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Funded Activity Summary

Neochromosomes are Frankenstein chromosomes--massive extra chromosomes that are stitched together from 100s of pieces of normal chromosomes. They are found in 3% of cancers, but are common in some types, such as liposarcoma. We have mapped their structure and found they form through punctuated chromosome shattering and gene amplification. We will investigate the precise molecular mechanisms that cause this and the recurrent transcriptional and epigenetic drivers lead to their formation.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $763,771.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genomics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bioinformatics | cancer research | functional genomics | genomic instability | genomics

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