Amyloid Precursor Protein Signalosome: directing Abeta production in Alzheimer's disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1103026

Funding Status
Closed

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Funded Activity Summary

Alzheimer's disease is the most common form of dementia and is the fourth biggest killer in developed countries. Amyloid precursor protein plays a central role in the development of the disease, through the generation of a toxic peptide called Abeta. In this project we will decipher the fine molecular details of what the protein looks like and how various molecules known to bind to it affect Abeta production. This knowledge is expected to lead to novel therapies to treat the disease.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $681,459.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | biophysics | crystallography | protein interactions | structural biology

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