How do mutations in autophagy receptors cause FTD and ALS?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1102977

Funding Status
Closed

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Funded Activity Summary

As cells age the "garbage disposal" process within cells slows down, becoming less functional. In inherited forms of dementia the genes involved often code for damaged proteins that "clog up" the disposal system or directly affect the “garbage men”. These defective garbage men genes include SQSTM1/p62, OPTN, VCP and UBQLN2. We will determine how these defective genes lead to build up of garbage in neuronal cells and how leads to disease.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Targeted Calls

Funding Amount: $566,966.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autophagy | cell signalling | dementia | protein interactions | proteomics

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