PROTEIN TARGETS FOR THE STEROID RECEPTOR MODULATOR, CYCLOPHILIN 40

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/110292

Funding Status
Closed

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Funded Activity Summary

Steroids bind to specific receptor proteins in steroid responsive cells. These receptors are kept in a steroid-binding ready state by chaperone proteins which function to fold the receptors appropriately. The major chaperone protein is heat shock protein, hsp90. A second family of proteins called immunophilins, cooperate with hsp90 in receptor folding. These immunophilins can bind to immunosuppressant drugs, which may result in a change in receptor function. We have identified one of these immunophilins as cyclophilin 40 ( CyP40), a protein that binds the immunosupressant drug, cyclosporin A. We have recently found that, in addition to binding to hsp90, CyP40 may bind to and regulate the function of other proteins which are important in how cells grow and die. The aims of this project are to study how CyP40 binds to hsp90 and to these other proteins and to determine the functional outcomes of these interactions.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $374,828.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

APOPTOSIS | CANCER | CELL PROLIFERATION | IMMUNOPHILINS | MOLECULAR CHAPERONES | OBESITY | REPRODUCTION | STEROID RECEPTORS

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