Age-Related Changes in Body Composition and Fuel Metabolism: The Role of Glucocorticoid Signalling in Osteoblasts

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1101879

Funding Status
Closed

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Funded Activity Summary

Our previous studies suggest that age related changes in fat tissue could be due to an increased level of glucocorticoids within bone forming cells (osteoblasts). Mice in which the level of glucocorticoids in osteoblasts is selectively decreased were no different from normal mice at a young age but with ageing were protected against development of obesity and diabetes. This project will examine how bone influences age related changes in fat mass and examine ways in which this might be prevented.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $820,528.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Systems Physiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ageing | diabetes mellitus | endocrinology | glucocorticoids | osteoblast

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