Single cell genetic profiling to reveal molecular and cellular changes in BRCA preneoplastic tissue

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1100807

Funding Status
Closed

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Funded Activity Summary

The initial molecular and cellular events that lead to breast cancer in women with BRCA1 or BRCA2 mutations are unknown. We will use state-of-the-art genomic tools (Single Cell RNA-seq and whole genome sequencing) to determine how cancer begins in absence of normal BRCA genes. Single cell genomic profiling of stem and daughter cells from pre-cancerous breast tissue will be used to identify early-indicator molecular changes that could be exploited in the clinic.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $202,959.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

BRCA1 | breast cancer | gene expression | stem cells | tumourigenesis

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