Understanding and manipulating long-range DNA looping in gene regulation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1100651

Funding Status
Closed

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Funded Activity Summary

The turning on and off of genes often involves physical interactions between the gene and other parts of the DNA that lie far away from the gene. Disruption of this gene regulation is likely to contribute to a wide range of diseases, including heart disease and cancer. This project seeks to better understand the complex puzzle of how the correct DNA connections are chosen over the large number of possible mis-connections, by trying to find the fundamental laws that control DNA-DNA interactions.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $351,025.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA structure | chromosomes | enhancer elements | gene regulation | mathematical modelling

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