Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1100443

Funding Status
Closed

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Funded Activity Summary

The timely generation of neurons and glia is important for brain development and consequently brain function throughout life. Nuclear factor I (NFI) genes are important for regulating the production of neurons and glia, and people with disrupted NFI genes have severe cognitive and motor deficits. Using human genetic data and mouse models, we will analyse how disrupting these genes affects brain development, and changes the overall structure and wiring of the cerebral cortex as well as behaviour.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $801,979.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

brain development | cerebral cortex | molecular mechanisms | neurodevelopmental disorders | neuroglia

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