ANTIGEN PRESENTATION IN CEREBRAL MALARIA PATHOGENESIS: A ROLE FOR BRAIN MICROVASCULAR ENDOTHELIUM AND MICROPARTICLES

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1099920

Funding Status
Closed

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Funded Activity Summary

We want to better understand how lesions occur in the brain during cerebral malaria. We focus our attention on the cells lining the brain blood vessels, called endothelial cells. The originality of this project is to study endothelial cells as immune cells. We already showed that they carry molecules enabling them to activate T lymphocytes and trigger inflammation. Knowing the fine mechanisms by which small brain vessels become damaged will help design better treatments for neuroinflammation.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $416,012.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antigen presenting cells | cerebral malaria | endothelium | immunoregulation | membrane biology

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