Structural events in insulin and IGF signalling - a nanodisc approach to a problem in cancer, diabetes and Alzheimer's disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1099595

Funding Status
Closed

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Funded Activity Summary

Insulin and its insulin-like growth factors play a major role in three major disease states facing ageing Australians—diabetes, cancer and Alzheimer's disease. We aim to understand how these proteins send messages into cells via their so-called receptors. We will isolate the receptor molecules from cells and then image them in an advanced electron microscope to produce three-dimensional images. Our findings will have implications for the design of therapeutics targeting the above three diseases.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $752,403.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

electron microscopy | insulin receptor | insulin-like growth factors (IGF) | receptor tyrosine kinase (RTK) | signal transduction

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