Pre-clinical assessment of the therapeutic potential of targeting the Hippo pathway in muscle wasting & muscle-derived cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1099588

Funding Status
Closed

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Funded Activity Summary

Recent findings have identified the Hippo signalling pathway as an important regulator of processes in muscle fibres and muscle progenitor cells. This project will look at the significance of the Hippo pathway in the development of muscle wasting caused by statin administration, and in the genesis of muscle derived tumors (rhabdomyosarcoma). The studies will determine if interventions that regulate the Hippo pathway could provide new therapies for these important muscle-related diseases.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $621,979.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Physiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell growth | cell signalling | signalling pathways | skeletal muscle wasting | statins

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