Role and potential for therapeutic targeting of dysfunction, oxidative stress and altered metabolism in mitochondria in the pathogenesis of COPD

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1099095

Funding Status
Closed

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Funded Activity Summary

Emphysema is a major cause of illness and death and there are no good treatments. It is caused by smoking that induces lung inflammation and disease but how this occurs is not well understood. Cellular respiration can become defective causing oxidative stress, altered metabolism and inflammation. We think that this drives emphysema. We will assess alterations in respiration, oxidative stress and metabolism in emphysema and see if we can reverse these changes with new potential treatments.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $720,338.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell metabolism | chronic obstructive pulmonary disease (COPD) | inflammation | mitochondrial function | oxidative stress

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