Mechanisms and treatment of upper airway collapse in obstructive sleep apnoea

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/109903

Funding Status
Closed

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Funded Activity Summary

Obstructive sleep apnoea (OSA) is characterized by intermittent closure of the upper airway (throat) resulting in episodes of decreased blood oxygen levels, increased blood pressure and disturbed sleep. Repetitive overnight arousals from sleep cause excessive daytime tiredness and lethargy, which have major consequences for social well-being and productivity in our community. OSA is a common condition, affecting as many as 2 to 4% of middle aged adults, and is associated with an increased cardiovascular risk, however the mechanisms underlying the increased upper airway collapsibility in individuals with OSA are not well understood. The proposed studies represent a series of investigations into fundamental mechanisms of neural and mechanical control of upper airway patency, how these mechanisms act to stabilize the upper airway, and whether these reflex control mechanisms can be manipulated to provide a novel treatment for OSA.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $328,668.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

daytime sleepiness | high frequency pressure oscillations | obstructive sleep apnoea | somnolence | treatment of obstructive sleep apnoea | treatment of upper airway obstruction | upper airway collapse | upper airway muscle reflexes

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