Glycosyltransferase effectors from bacterial enteric pathogens

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1098826

Funding Status
Closed

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Funded Activity Summary

Many disease-causing microbes subvert host cell defences to establish infection in part by transporting virulence proteins, termed “effector” proteins, into host cells via specialized protein secretion systems. We have discovered a new family of bacterial effectors that modify host proteins with a sugar and thereby inactivate them. Here we will characterise the function of these effector proteins during infection with E. coli and Salmonella.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $772,600.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bacterial gastroenteritis | bacterial virulence | enzyme-protein interactions | infection | innate immunity

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