Targeting microvascular dysfunction in severe malaria

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1098334

Funding Status
Closed

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Funded Activity Summary

In severe malaria blood vessels cannot make enough protective nitric oxide (NO). The gel-like lining of blood vessels (glycocalyx) is needed to produce NO, but this is damaged in some severe infections. We will test whether glycocalyx is lost in malaria and how it affects blood vessel NO and function in human volunteer infections and in patients with and without severe malaria. We will test whether a salt nitrite, can be used to safely increase NO and blood vessel function in severe malaria.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $871,923.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Falciparum malaria | endothelial function | malaria | microvascular | nitric oxide

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