Mechanistic characterisation of the epigenetic modifier Smchd1

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1098290

Funding Status
Closed

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Funded Activity Summary

FSHD is a progressive muscular dystrophy that currently has no treatment or cure. SMCHD1 is known to play an important role in FSHD, where its usual function in switching genes off is imperfect, contributing to disease. In this project we will determine how SMCHD1 switches genes off and what SMCHD1 looks like at the molecular level, so that we can elucidate how to boost SMCHD1 function for FSHD therapy.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $1,197,133.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biochemistry | bioinformatics | epigenetics | muscle degeneration | structural biology

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