Analysis of proinsulin-epitope specific CD4+ T cells in blood of people with type 1 diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1094337

Funding Status
Closed

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Funded Activity Summary

Type 1 diabetes (T1D) is an incurable autoimmune disease characterised by T-cell mediated destruction of insulin-secreting cells of the pancreas. Development of preventative therapies is hampered by paucity of knowledge regarding the targets of the autoimmune T-cell response. We have recently identified epitopes ‘seen’ by islet-infiltrating T-cells, located in proinsulin. Our aim is to examine proinsulin-specific T-cell responses in the peripheral blood of people with and without T1D.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Postgraduate Scholarships

Funding Amount: $122,834.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell epitope | T cell immunity | autoimmune disease | diabetes prevention | type 1 diabetes mellitus (insulin-dependent diabetes mellitus)

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