In vivo investigation of human PR3 transgenic mice: a novel animal model to understand the role of PR3 in chronic inflammation and autoimmune vasculitis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1092602

Funding Status
Closed

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Funded Activity Summary

Granulomatosis with polyangiitis (GPA) is a form of vasculitis and is associated with antibodies directed against proteinase 3 (PR3). PR3 is expressed in neutrophils, monocytes and macrophages and has a number of well-characterized pro-inflammatory functions. The aim of this project is to understand the role of PR3 in inflammation and autoimmune vasculitis in vivo. This will be achieved using a transgenic mouse model expressing human PR3.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2020

Funding Scheme: Early Career Fellowships

Funding Amount: $378,615.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autoimmune disease | inflammation | innate immunity | mouse models | vasculitis

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