Mechanisms responsible for neurogenic hypertension: a novel interaction between GABAergic modulation of amygdalo-hypothalamic pathways and microRNA regulation of renin

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1091688

Funding Status
Closed

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Funded Activity Summary

A genetic model of hypertension will be used to understand the interrelated role of the brain, nervous system and kidney. The proposed studies will test the hypothesis that disruption of inhibitory neurochemicals in specific regions of the brain, leads to greater nervous system activation of the kidney, which in turn decreases an inhibitory molecule, ultimately resulting in greater activation of a hormonal system responsible for raising blood pressure.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2020

Funding Scheme: Early Career Fellowships

Funding Amount: $340,220.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

central autonomic control | hypertension | microrna | renin-angiotensin system (RAS) | sympathetic nervous system

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