Contribution of MDSC-derived cysteine cathepsins in breast cancer metastasis to bone

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1091636

Funding Status
Closed

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Funded Activity Summary

Cathepsins are enzymes called proteases that function to cleave specific proteins, a process that is important for many normal cellular functions. Aberrant cathepsin activity can result in a number of pathologies, including cancer and inflammation. We are developing tools called activity-based probes to study the function of cathepsins in disease. Specifically, we will investigate their activity within cells of the immune system with the goal of developing novel therapeutic approaches.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Early Career Fellowships

Funding Amount: $320,891.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Molecular Targets

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone metastasis | breast cancer | functional imaging | microenvironment | protease

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