Isolation and pre-clinical evaluation of small molecule anti-inflammatory compounds from hookworms

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1091011

Funding Status
Closed

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Funded Activity Summary

This project will harness the unique ability of hookworm small molecules (<10 kDa) to modulate inflammation, and exploit these properties to develop novel modalities to treat inflammatory bowel diseases, using millennia of host-parasite coevolution as a guide. The excretory/secretory and somatic extracts will be assessed for their anti-inflammatory properties using TNBS mouse model. Compounds will be separated using HPLC and identified using MS and NMR spectroscopy.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Early Career Fellowships

Funding Amount: $320,891.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

anti-inflammatory agents | autoimmune disease | drug discovery | inflammatory bowel disease (IBD) | medicinal chemistry

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