Investigation of two GPCRs implicated in tumour progression: PAR1 and LGR5

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1090993

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

G-protein-coupled-receptors (GPCRs) belong to a large and diverse family of membrane proteins. Due to their number, diversity and critical roles in signaling, GPCRs offer extraordinary opportunities for development of novel drugs. However, our rudimentary understanding of their mechanism of activation and subsequent signaling do not support rational drug design. This project focuses on two receptors, PAR-1 and LGR5, to gain insights into the activation mechanisms and signalling of GPCRs.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2021

Funding Scheme: Early Career Fellowships

Funding Amount: $404,689.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G-protein coupled receptors | biochemistry | cell biology | crystallography | structural biology

Related Links