The early life origin of airway smooth muscle thickening in asthma pathogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1090888

Funding Status
Closed

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Funded Activity Summary

Previous studies have shown that fetal growth restriction (FGR) in the womb is associated with asthma in children; however the reason remains unknown. Thickening of the airway smooth muscle (ASM) is the primary structural abnormality in asthma. A model of FGR caused by low oxygen in the womb will be used to determine if associations between FGR and asthma involve an early life increase in ASM. That ASM may be increased from birth is a novel hypothesis which challenges conventional thinking.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2019

Funding Scheme: Early Career Fellowships

Funding Amount: $322,198.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

airway hyper-responsiveness | airway smooth muscle | asthma | growth restriction | hypoxia

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