Deciphering IFN type III, TGF?, IL-10 and adenosine pathways in natural killer cells: enhancing the innate anti-metastatic response against breast cancer progression

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1088703

Funding Status
Closed

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Funded Activity Summary

This project will determine whether one or more factors produced in tumours (eg. cell hormones and metabolites) inhibits NK cells from controlling breast cancer spread using the best available mouse tumour models. We will use genetics to specifically delete response to these factors by NK cells. It is a completely novel approach and this information will allow for the more rational design of cancer treatments following surgery and local radiotherapy and/or chemotherapy.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Early Career Fellowships

Funding Amount: $320,891.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Tumour Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

immune evasion | immune modulation | immune suppression | immune surveillance | immune tolerance

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