Immune-modifying-particle-induced Tregs induce remission in experimental autoimmune encephalomyelitis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1088242

Funding Status
Closed

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Funded Activity Summary

Multiple Sclerosis is a debilitating autoimmune disease of the central nervous system. Disease is the result of inflammatory monocyte-derived dendritic cells that migrate from the blood into the brain, where they stimulate T cells to attack myelin sheaths around neurons. Our novel therapy, known as immune modulating micro-particles reduces monocyte migration and disease in a mouse model, we hypothesize, by inducing immunosuppressive T regulatory cells that control attacking T cells in MS.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $512,440.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nanobiotechnology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

experimental autoimmune encephalomyelitis (EAE) | inflammation | monocytes | nanotechnology | regulatory T cells

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