Exploiting the pharmacokinetic and pharmacodynamic properties of bile acid receptor agonists to treat liver disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1087297

Funding Status
Closed

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Funded Activity Summary

We have generated preliminary data suggesting that chemicals made by the liver, called bile acids, act on fat cells to release a hormone called adiponectin. In liver disease adiponectin has favorable effects, including reducing liver inflammation and fibrosis (scarring). By using drugs that mimic the action of bile acids we expect that adiponectin production by fat cells can be increased, creating a new way to treat patients with chronic liver diseases.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $653,952.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bile acids | pharmacodynamics | pharmacokinetics | pharmacology | therapeutics

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