Development of novel anti-cancer agents based on cytochrome P450-mediated epoxides of omega-3 fatty acids

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1087248

Funding Status
Closed

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Funded Activity Summary

There are few effective treatments for advanced breast cancer. Dietary ?-3 and ?-6 fatty acids respectively decrease and increase the risk of cancer spread. We have found that ?-3 fatty acid epoxide metabolites inhibit the growth of tumour cells and have prepared analogues that are highly active in vivo in animal models of breast cancer. This project will improve and optimise these agents that hold promise as a new class of anti-cancer drugs with the potential to treat advanced disease.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $949,433.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmaceutical Sciences

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytochrome P450 | drug development | lipid metabolism | medicinal chemistry | signalling pathways

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