A study of the origins of macrophages in healthy and atherosclerotic vasculature focusing on a novel population of resident adventitial macrophage progenitor cells (AMPCs)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1086796

Funding Status
Closed

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Funded Activity Summary

White blood cells (macrophages) play a key role in the development of atherosclerosis, the underlying cause of most heart attacks and strokes. We have made new discoveries to show that there are stem (progenitor) cells for macrophages that exist within the outer lining of blood vessels. This project will study whether these local progenitor cells, called AMPCs, are a source of macrophages in atherosclerosis and in turn could lead to new treatment approaches for cardiovascular disease.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $465,345.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

atherosclerosis | macrophages | progenitor cells | vascular development | vascular remodelling

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