The role of the homeobox transcription factor Hhex in haematopoiesis and leukaemia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1085765

Funding Status
Closed

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Funded Activity Summary

We have shown that the Haematopoietically expressed homeobox (Hhex) protein plays important roles in development of immune cells. In addition, Hhex is required for development and maintenance of Acute Myeloid Leukemia (AML). This project will further investigate the requirement of Hhex in human AML, potentially identifying a new therapeutic target in this poor-prognosis cancer subtype. In addition, we will identify critical cofactors and targets of Hhex, revealing new therapeutic strategies.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $623,112.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

haematopoietic stem cells | homeobox genes | leukaemogenesis | lymphocyte differentiation | transcription factor

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