A Novel Metabolic Role for UDP Glycosyltransferase 8 (UGT8)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1085410

Funding Status
Closed

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Funded Activity Summary

The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $419,144.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

UDP-glucuronosyltransferase | bile acids | drug conjugation | drug metabolism | molecular pharmacology

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