Molecular basis of Ca2+-dependent disruption of EC-coupling and weakness in skeletal muscle

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1085331

Funding Status
Closed

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Funded Activity Summary

One major cause of weakness in skeletal muscle appears to stem from damage to the mechanism controlling release of calcium ions from internal stores and consequent contraction. This project examines whether the damage is due to excessive levels of intracellular calcium ions activating enzymes that cut a particular vital molecule controlling calcium release. The findings could identify a major factor in muscle weakness in muscular dystrophy and other conditions and lead to specific therapies.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $530,976.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Physiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

excitation-contraction coupling | muscle contraction | muscle disease | muscle physiology | muscular dystrophy

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