Uncovering novel roles of Escherichia coli flagella and LPS in uropathogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1084889

Funding Status
Closed

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Funded Activity Summary

Urinary tract infections (UTI) are common infectious diseases in humans. Uropathogenic Escherichia coli (UPEC) cause most UTI. UPEC produce factors that promote their survival and influence disease such as flagella. We have identified anti-inflammatory responses as a key element of UTI and have shown that these responses contribute to control of UTI. In this project, we will investigate how the UPEC flagella component, FliC, contributes to anti-inflammatory responses and what this means for UTI.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $404,677.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Escherichia coli | bacterial pathogenesis | flagella | microbial pathogenesis | virulence factors

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