Chromatin regulation of neural stem cell multipotency

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1084352

Funding Status
Closed

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Funded Activity Summary

The genetic material is packaged in the cell nucleus with histone proteins. Chemical modifications of histones determine if a particular area of the genome is active or repressed. We are investigating a family of histone modifying proteins, the MYST proteins. Mutations in these proteins cause intellectual disability and cancer. In this project we examine the role of MYST2 in brain stem cells. Knowledge gained may become the basis for the development of drugs to treat neurodegenerative disease.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $756,142.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chromatin | developmental genetics | gene targeting | stem cells | transcriptional regulation

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