Abnormal lung iron homeostasis in cystic fibrosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1084130

Funding Status
Closed

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Funded Activity Summary

The lung in people with the genetic disorder cystic fibrosis (CF) contains increase amounts of iron, which promotes bacterial infection. In this research project we are using mouse models of CF and airway cells obtained from people with CF to investigate the underlying mechanism of abnormal iron regulation. We are also examining the therapeutic potential of compounds that interfere with the ability of bacteria to obtain iron to see whether this can overcome antibiotic resistance.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $650,010.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Pseudomonas aeruginosa infection | cystic fibrosis | iron | iron chelators | iron metabolism

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