Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and the production of Abeta amyloid peptides

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1082600

Funding Status
Closed

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Funded Activity Summary

The development of Alzheimer’s disease results from the generation of toxic peptides by the cleavage of a membrane protein by an enzyme called BACE. A key feature of which regulates the generation of toxic peptides involves the movement of BACE between compartments in the cell by a process known as membrane transport. Our recent work has identified the itinerary of BACE in the cell. The studies here will reveal the molecular machinery of the BACE pathway in neurons. This fundamental informati

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $705,984.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

amyloid precursor protein | endosomes | membrane biology | membrane transport | protein trafficking

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