Determining the contribution of peripheral immune complement signalling in the progression of motor neuron disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1082271

Funding Status
Closed

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Funded Activity Summary

Motor neuron disease (MND) is a debilitating and lethal neurodegenerative disease, which has no effective treatment. We propose that an overactive immune system is a major contributing factor in this disease. To test this, we will examine immune pathways in patients suffering from MND, and will test a novel immune-modulatory drug in animal models of MND. We hope to identify new therapeutic avenues to slow disease progression, and improve the quality of life in patients diagnosed with MND.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $1,000,871.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurosciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

complement C5a | inflammation | monocyte/macrophage | motor neuron disease (MND) | neurodegeneration

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