STABILISING G PROTEIN-COUPLED RECEPTORS FOR DRUG DISCOVERY

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1081801

Funding Status
Closed

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Funded Activity Summary

Prescription drugs targeting human proteins called GPCRs are sold as effective treatments for many diseases. However, there are over 800 different types of GPCRs in the human body and only a small fraction is targeted by drugs, mainly because GPCRs are unstable and thus difficult to work with in the laboratory. We are applying newly developed technologies to engineer stabilised ?1-adrenoceptors, a class of GPCRs, for drug discovery against cardiovascular diseases, epilepsy and neurodegeneration

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $628,140.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmaceutical Sciences

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G protein-coupled receptors | adrenoceptors | drug discovery | nuclear magnetic resonance (NMR) spectroscopy | protein engineering

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