IL-22 as a Suppressor of Pancreatic ?-Cell Stress and a Treatment for Diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1081473

Funding Status
Closed

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Funded Activity Summary

Type 2 diabetes occurs when pancreatic beta cells fail to produce enough insulin to control blood sugar levels. We have discovered that the IL-22 protein produced by immune cells protects beta cells from stress. Diabetic mice given IL-22 show restored control of blood sugar levels. The proposed research will take steps to safely introduce IL-22 based therapy into the clinic and gain a deeper understanding of the mechanisms of action of IL-22.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $854,490.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytokines | inflammation | insulin secretion | pancreas | type 2 diabetes mellitus (non-insulin dependent diabetes mellitus)

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