Altering macrophage phenotype for the treatment of chronic airway disease and lung cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1081373

Funding Status
Closed

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Funded Activity Summary

The aim of this proposal is to identify mechanisms through which the Src family kinase Hck promotes innate immune cell-dependent, chronic lung inflammation and lung cancer development. Our preliminary data suggest that excessive Hck activity provides a molecular mechanism to skew macrophage polarization towards an alternatively activated, M2-like phenotype associated with chronic airways disease, and the tumour promoting microenvironment.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $904,556.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Physiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Src-family tyrosine kinases | chronic obstructive pulmonary disease (COPD) | lung cancer | macrophages | mouse models

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