Targeting Schistosome Calcium Signalling to Improve and Broaden Praziquantel Efficacy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1080007

Funding Status
Closed

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Funded Activity Summary

Schistosomiasis is caused by parasitic worms, treatment relies solely on praziquantel (PZQ). Schistosomes respond and recover from PZQ exposure through modulation of the gene CamKII. We will target this gene to both increase and extend the efficacy of PZQ in both adult parasites and in refractory juvenile parasites. Research will expand into assaying CamKII inhibitors to maximise effectiveness and take this work into animal models of this disease.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $481,661.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Schistosoma | calcium regulation | drug efficacy | helminth infection | schistosomiasis

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