Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer’s disease risk.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1079995

Funding Status
Closed

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Funded Activity Summary

We recently discovered that a protein called apoE is cleaved in the brain to generate a small fragment that may have neuroprotective properties. We also discovered that human induced pluripotent stem cell (iPSC)-derived neurons produce apoE fragments identical to those in the brain. We will now characterise iPSC apoE and assess its neuroprotective properties. This will resolve the basis for the association of apoE with AD risk and potentially provide a new target for AD treatment.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $429,495.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | amyloid beta-protein | apolipoprotein E | molecular neuroscience | neurobiology

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