NOD1 sensing of H. pylori peptidoglycan promotes cell survival and bacterial persistence

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1079930

Funding Status
Closed

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Funded Activity Summary

The bacterium H. pylori lives in the stomach of half the world’s population and is a major cause of human disease, including peptic ulcers and stomach cancer. This project will investigate how H. pylori is able to manipulate the host immune system by modifying the composition of its outside layer (the cell wall). In so doing, H. pylori causes changes in cells of the stomach lining that allow the bacterium to persist, but that also may predispose the host to cancer.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $792,492.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Helicobacter pylori | host response | host/pathogen interaction | pathogenic bacteria | virulence

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