Role of MACROD2 Loss in DNA Repair, Chromosomal Instability and Development of Colorectal Cancer: Clinical and Therapeutic Implications

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1079364

Funding Status
Closed

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Funded Activity Summary

The MACROD2 gene is deleted in one-third of human bowel cancers. We have discovered that MACROD2 deletion causes defective DNA repair and tumour chromosomal instability. Here, we will use novel laboratory models to show that MACROD2 loss actively promotes bowel cancer development. We will test the clinical implication of MACROD2 loss for predicting tumour therapy response and will investigate the potential of exploiting this deficiency for drug targeting.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $772,871.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA repair | cancer biology | colorectal cancer | mouse models | tumour suppressor

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