High-Throughput Discovery of Synergistic Drug Combinations for Metastatic Colorectal Cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1079362

Funding Status
Closed

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Funded Activity Summary

Treatment outcomes for patients with metastatic bowel cancer remain poor, with most tumours developing resistance within 24 months. A key problem is that cancers are genetically diverse, with some cells inevitably resistant to any given treatment. This study aims to discover effective drug combinations targeting distinct essential tumour cell functions through robotics-based pairwise testing of known drugs on bowel cancer cell lines representing the genetic diversity of the disease.

Funded Activity Details

Start Date: 01-01-2015

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $1,526,568.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Therapy (excl. Chemotherapy and Radiation Therapy)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biomarkers | colorectal cancer treatment | combination therapy | drug discovery | molecular mechanisms

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